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digoxin is also used to treat atrial fibrillation, a heart rhythm disorder of the atria the upper chambers of the heart that allow blood to flow into the heart .
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digoxin is a selective inhibitor of the plasma membrane sodium pump.
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if the assay being used is sensitive to these substances, it may be prudent to obtain a baseline measurement before digoxin therapy is started, and correct later values by the reported baseline level.
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sitagliptin is a p-glycoprotein substrate, but does not inhibit p-glycoprotein mediated transport of digoxin.
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digoxin use is relatively contraindicated in patients with ventricular arrhythmias including premature ventricular contractions or ventricular tachycardia because the drug can exacerbate these arrhythmias.
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